منابع مشابه
The intracrine renin-angiotensin system.
The RAS (renin-angiotensin system) is one of the earliest and most extensively studied hormonal systems. The RAS is an atypical hormonal system in several ways. The major bioactive peptide of the system, AngII (angiotensin II), is neither synthesized in nor targets one specific organ. New research has identified additional peptides with important physiological and pathological roles. More pepti...
متن کاملOn the Intracrine Renin-Angiotensin System
The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under norm...
متن کاملThe mitochondrial component of intracrine action.
In recent years the actions of intracellular-acting, extracellular signaling proteins/peptides (intracrines) have become increasingly defined. General principles of intracrine action have been proposed. Mitochondria represent one locus of intracrine action, and thus far, angiotensin II, transforming growth factor-beta, growth hormone, atrial natriuretic peptide, Wnt 13, stanniocalcin, other ren...
متن کاملThe nature of intracrine peptide hormone action.
Current theory holds that peptide hormone action results from hormone binding to cell-surface receptors, with the generation of intracellular second messengers. However, a growing body of evidence suggests that intracellular peptide hormone, either internalized or synthesized in situ, can exert physiologically relevant effects. These effects are diverse and poorly understood. I propose that suc...
متن کاملIntracellular renin-angiotensin system: the tip of the intracrine physiology iceberg.
IT IS AXIOMATIC THAT PEPTIDE hormones bind to cognate receptors on target cells, with the resultant generation of intracellular second messengers. Not as well known is the fact that a large and growing body of evidence indicates that extracellular signaling peptides, such as hormones and growth factors, also appear, in some cases, to operate in the interiors of cells after internalization or re...
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ژورنال
عنوان ژورنال: Clinical Science
سال: 2012
ISSN: 0143-5221,1470-8736
DOI: 10.1042/cs20120089